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Published November 14, 2017 | Published + Supplemental Material
Journal Article Open

Non-neuronal cell outgrowth in C. elegans


Cell outgrowth is a hallmark of some non-migratory developing cells during morphogenesis. Understanding the mechanisms that control cell outgrowth not only increases our knowledge of tissue and organ development, but can also shed light on disease pathologies that exhibit outgrowth-like behavior. C. elegans is a highly useful model for the analysis of genes and the function of their respective proteins. In addition, C. elegans also has several cells and tissues that undergo outgrowth during development. Here we discuss the outgrowth mechanisms of nine different C. elegans cells and tissues. We specifically focus on how these cells and tissues grow outward and the interactions they make with their environment. Through our own identification, and a meta-analysis, we also identify gene families involved in multiple cell outgrowth processes, which defined potential C. elegans core components of cell outgrowth, as well as identify a potential stepwise cell behavioral cascade used by cells undergoing outgrowth.

Additional Information

© 2017 Taylor & Francis. Received 11 Sep 2017, Accepted 30 Oct 2017, Accepted author version posted online: 14 Nov 2017, Published online: 14 Nov 2017. We thank Mihoko Kato and reviewers for critical reading of the manuscript. P.W.S. is an investigator of the Howard Hughes Medical Institute. S.G. was supported by National Institutes of Health training grant GM07616. S. V. was supported by the American Society of Cell Biology Minorities Affairs Committee Visiting Professor's Program, which was funded by the Howard Hughes Medical Institute grant number 047101. No potential conflicts of interest were disclosed.

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Published - kwrm-06-3-4-1405212.pdf

Supplemental Material - kwrm_a_1405212_sm6270.xlsx


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