CaltechAUTHORS
Published March 24, 2003 | Version public
Journal Article Metadata-only

Neural prosthetic control signals from plan activity

Creators

  • 1. ROR icon Nokia (United States)

Abstract

The prospect of assisting disabled patients by translating neural activity from the brain into control signals for prosthetic devices, has flourished in recent years. Current systems rely on neural activity present during natural arm movements. We propose here that neural activity present before or even without natural arm movements can provide an important, and potentially advantageous, source of control signals. To demonstrate how control signals can be derived from such plan activity we performed a computational study with neural activity previously recorded from the posterior parietal cortex of rhesus monkeys planning arm movements. We employed maximum likelihood decoders to estimate movement direction and to drive finite state machines governing when to move. Performance exceeded 90% with as few as 40 neurons.

Additional Information

© 2003 Lippincott, Williams & Wilkins. We thank B.L. Gillikin, J. Wynne, J. Baer and J.S. Pezaris for expert advice and assistance in designing and performing the surgery to implant a chronic electrode array in PRR. We also thank E.M. Maynard, B.W. Hatt, R.A. Normann, N.G. Hatsopoulos and J.P. Donoghue for surgical and electrode-array advice related to this surgery. We thank M. Sahani for writing the real-time behavioral control and data collection software HYDRA2, D.J. Dubowitz for pre-surgical MRI and R.A. Normann for lending us LFP amplifiers. Finally, we thank B.L. Gillikin for veterinary assistance, Cierina Marks for administrative assistance and Viktor Shcherbatyuk for computer assistance. This work was supported in part by NIH, DARPA, ONR, Sloan Center for Theoretical Neurobiology at Caltech, McKnight Foundation, NSF Engineering Research Center at Caltech, James G. Boswell Neuroscience Professorship (R.A.A.), and Burroughs Wellcome Fund Career Award in the Biomedical Sciences (K.V.S.).

Additional details

Identifiers

Eprint ID
102227
DOI
10.1097/00001756-200303240-00013
Resolver ID
CaltechAUTHORS:20200401-091008965

Related works

Describes
10.1097/00001756-200303240-00013 (DOI)

Funding

NIH
Defense Advanced Research Projects Agency (DARPA)
Office of Naval Research (ONR)
Sloan-Swartz Center for Theoretical Neurobiology
McKnight Foundation
NSF
James G. Boswell Foundation
Burroughs Wellcome Fund

Dates

Created
2020-04-01
Created from EPrint's datestamp field
Updated
2021-11-16
Created from EPrint's last_modified field