Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published August 2018 | Accepted Version
Journal Article Open

Peripheral and Central Nutrient Sensing Underlying Appetite Regulation


The precise regulation of fluid and energy homeostasis is essential for survival. It is well appreciated that ingestive behaviors are tightly regulated by both peripheral sensory inputs and central appetite signals. With recent neurogenetic technologies, considerable progress has been made in our understanding of basic taste qualities, the molecular and/or cellular basis of taste sensing, and the central circuits for thirst and hunger. In this review, we first highlight the functional similarities and differences between mammalian and invertebrate taste processing. We then discuss how central thirst and hunger signals interact with peripheral sensory signals to regulate ingestive behaviors. We finally indicate some of the directions for future research.

Additional Information

© 2018 Elsevier Ltd. Available online 18 June 2018. We thank the Oka lab members and A. Dahanukar for valuable comments. Y.O. is supported by the Searle Scholars Program, the Mallinckrodt Foundation, the McKnight Foundation, the Klingenstein-Simons Foundation, and NIH U01 (U01 NS099717).

Attached Files

Accepted Version - nihms966472.pdf


Files (861.4 kB)
Name Size Download all
861.4 kB Preview Download

Additional details

August 21, 2023
October 18, 2023