Published June 3, 2015
| Accepted Version + Supplemental Material
Journal Article
Open
Stereochemical evaluation of bis(phosphine) copper catalysts for the asymmetric alkylation of 3-bromooxindoles with α-arylated malonate esters
Abstract
An improved method for the asymmetric alkylation of 3-bromooxindoles with α-arylated malonate esters is described. The asymmetric alkylation demonstrated was achieved up to 70% ee utilizing a copper(II) bis(phosphine) complex.
Additional Information
© 2014 Elsevier B.V. Received 30 September 2014; Received in revised form 24 October 2014; accepted 27 October 2014. The authors wish to thank NIH-NIGMS (R01GM080269-01), Amgen, the Gordon and Betty Moore Foundation, and Caltech for financial support. S.-J.H thanks Fulbright Commission (Foreign Student Program, No. 15111120) and the Ilju Foundation of Education & Culture (Pre-doctoral Research Fellowship) for financial support. Catalyst center (Caltech) is acknowledged for assistance with reaction screenings. Drs. Florian Vogt, Sandy Ma, Xiaoquing Han, and Shyam Krishnan are acknowledged for preliminary research.Attached Files
Accepted Version - nihms-638763.pdf
Supplemental Material - mmc1.pdf
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Additional details
- PMCID
- PMC4429905
- Eprint ID
- 51486
- DOI
- 10.1016/j.tet.2014.10.065
- Resolver ID
- CaltechAUTHORS:20141110-091731285
- NIH
- R01GM080269-01
- Amgen
- Gordon and Betty Moore Foundation
- Caltech
- Fulbright Commission
- 15111120
- Ilju Foundation of Education & Culture
- Created
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2014-11-10Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field