M-mode photoacoustic flow imaging
Recently, there has been a growing interest in the development of photoacoustic flow measuring methods aimed to study microvascular blood flow in deep tissue. Here, we describe a method of M-mode photoacoustic flow imaging, where a photoacoustic microscope equipped with a high repetition rate pulsed dye laser is used. As a demonstration, we studied the flow of a diluted suspension of carbon glassy particles in a small tube, and extracted the flow profile. Potentially, the method can be applied to detect the blood flow in microvessels either directly or by injecting optically absorbing particles.
Additional Information© 2009 Society of Photo-Optical Instrumentation Engineers (SPIE). We acknowledge the support provided by National Institutes of Health under grants R01 EB000712 and R01 NS046214. We thank Song Hu and Erich Stein for the useful discussion.
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