CaltechAUTHORS
Published February 27, 2004 | Version Supplemental Material
Journal Article Open

A Mild and Efficient Synthesis of Oxindoles: Progress Towards the Synthesis of Welwitindolinone A Isonitrile

Creators

Abstract

The complete carbon skeleton of welwitindolinone A isonitrile has been prepared by using a [2+2] cycloaddition to establish the bicyclo[4.2.0]octane core and a SmI2-mediated intramolecular reductive cyclization between an enone and an aryl isocyanate to stereoselectively install the spiro-oxindole (see scheme; DBU=1,8-diazabicyclo[5.4.0]undec-7-ene).

Additional Information

© 2004 WILEY-VCH Verlag GmbH & Co. Issue online: 25 Feb 2004. Version of Record online: 11 Feb 2004. Manuscript Received: 10 Nov 2003. We gratefully acknowledge financial support from Yamanouchi, Merck, Pfizer, and Amgen. J.M.R. is the recipient of an NIH postdoctoral fellowship. K.R. thanks Sankyo Co., LTD.; M.H. thanks Daiso Co., LTD., M.M.W. thanks Bristol Myers Squibb for a graduate fellowship.

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Additional details

Identifiers

Eprint ID
75662
DOI
10.1002/anie.200353282
Resolver ID
CaltechAUTHORS:20170404-071621138

Related works

Describes
http://onlinelibrary.wiley.com/wol1/doi/10.1002/anie.200353282/suppinfo (URL)

Funding

Yamanouchi
Merck
Pfizer
Amgen
Bristol-Myers Squibb
NIH Postdoctoral Fellowship
Sankyo Co., Ltd.
Daiso Co., Ltd.

Dates

Created
2017-04-04
Created from EPrint's datestamp field
Updated
2021-11-15
Created from EPrint's last_modified field