CaltechAUTHORS
Published November 1986 | Version Published
Journal Article Open

Abelson Virus Abrogation of Interleukin-3 Dependence in a Lymphoid Cell Line

Creators

Abstract

Among several tyrosine-protein kinases, only v-abl could abrogate interleukin 3 dependence of a lymphoblastoid cell line; v-src and v-fps proteins gave partial or no interleukin 3 independence, respectively. Lymphokine independence was achieved via a nonautocrine mechanism. Direct involvement of c-myc in this process was not evident.

Additional Information

© 1986 American Society for Microbiology. Received 17 April 1986; Accepted 3 July 1986. We thank Alan Korman (Whitehead Institute, Cambridge, Mass.) for his gift of pDOL plasmid. We are grateful to Bob Finkelstein for his critical reading of the manuscript and especially to Nancy Andrews for valuable suggestions on the manuscript and critical discussion of the experiments. This work was supported by grant CA38497 from the National Cancer Institute. B.M.-P. is a recipient of a fellowship from the Helen Hay Whitney Foundation; G.N. was supported by Howard Hughes Medical Institute, Boston, Mass.

Attached Files

Published - MATmcb86.pdf

Files

MATmcb86.pdf

Files (650.0 kB)

Name Size Download all
md5:2f2ae6256b2dca2c82291f39ecf74766
650.0 kB Preview Download

Additional details

Identifiers

PMCID
PMC367185
Eprint ID
32132
Resolver ID
CaltechAUTHORS:20120627-095332043

Related works

Describes
10.1128/MCB.6.11.4133 (DOI)

Funding

NIH
CA38497
Helen Hay Whitney Foundation
Howard Hughes Medical Institute (HHMI)
National Cancer Institute

Dates

Created
2012-06-27
Created from EPrint's datestamp field
Updated
2021-11-09
Created from EPrint's last_modified field