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Published December 6, 2019 | Supplemental Material
Journal Article Open

Progress toward the Enantioselective Synthesis of Curcusones A–D via a Divinylcyclopropane Rearrangement Strategy


We report our iterative efforts toward the divergent total syntheses of curcusones A–D via Suzuki coupling, intramolecular cyclopropanation, and a key divinylcyclopropane rearrangement. Progress of our synthesis was repeatedly challenged by the highly substrate-dependent cyclopropanation step, which we could ultimately overcome by judicious choice of substituents on the six-membered ring fragment.

Additional Information

© 2019 American Chemical Society. Received: October 27, 2019. Publication Date:November 25, 2019. We thank NSF (CHE-1800511), Amgen, and Caltech for funding this research. Author Contributions: A.C.W. and C.W.L. contributed equally. The authors declare no competing financial interest.

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