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Published January 28, 1998 | Supplemental Material
Journal Article Open

Exploiting Polypeptide Motifs for the Design of Selective Cu(II) Ion Chemosensors


The production of fluorescent devices for the sensing and reporting of chemical events is currently of significant importance for both chemistry and biology. More specifically, sensors directed toward the detection and measurement divalent copper have enjoyed particular attention. Our focus has been on the production of robust, small-molecule chemosensors that exhibit reversible signaling and operate in aqueous solution at neutral pH, without the requirement for organic cosolvents. Because the intended use for such a sensor is ultimately for the measurement of environmental or biological samples, sufficient detection selectivity is of prime concern to ensure that a measurement in the appropriate concentration range can be made, even in the presence of elevated levels of competing divalent cations.

Additional Information

© 1998 American Chemical Society. Received September 25, 1997; Revised Manuscript Received November 26, 1997. Publication Date (Web): January 7, 1998. We thank Dr. M. Meldal of the Carlsberg Laboratory, Department of Chemistry, for the generous gift of PEGA-1900. This research was supported by the NSF and the Gates Foundation. The award of a NIH pre-doctoral training grant in biology and chemistry to G.K.W. (GM07616) and postdoctoral fellowships from NATO and Xunta de Galicia (to A.T.) are also gratefully acknowledged.

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