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Published January 27, 1967 | public
Journal Article

Mechanism of Antibody Synthesis: Size Differences between Mouse Kappa Chains


Structural analysis of immunoglobulin light chains has been carried out in an attempt to elucidate the genetic mechanisms involved in antibody synthesis. Analysis of two mouse kappa-chain proteins is almost complete. The differences are localized in one-half of the molecules, and do not reflect the operation of any one mutational mechanism. The peculiar character of the differences is discussed with reference to various theories of antibody formation. The finding that the two proteins differ in size is incompatible with certain proposed theories.

Additional Information

© 1967 American Association for the Advancement of Science. 21 November 1966. We thank J. Smith, U. Heidrich, and J. Raes for technical assistance. Supported by USPHS research grant GM-0-6965 and USPHS postdoctoral fellowship (1-F2-GM-20, 388-02) (L.H.).

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