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Published 2006 | Submitted
Book Section - Chapter Open

Scaffolded DNA origami: from generalized multi-crossovers to polygonal networks


My acquaintance with Ned Seeman began in the Caltech library sometime during 1992. At the time, I was trying to design a DNA computer and was collecting papers in an attempt to learn all the biochemical tricks ever performed with DNA. Among the papers was Ned and Junghuei Chen's beautiful construction of a DNA cube [2]. I had no idea how to harness such a marvel for computation - the diagrams explaining the cube were in a visual language that I could not parse and its static structure, once formed, did not seem to allow further information processing. However, I was in awe of the cube and wondered what kind of mad and twisted genius had conjured it.

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© 2006 Springer. I thank Erik Winfree and William Shih for comments and the Caltech Center for the Physics of Information for a postdoctoral fellowship.

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January 13, 2024