G Protein-Coupled Odorant Receptors: from sequence to structure
Odorant receptors (ORs) are the largest sub-family within Class-A G Protein-Coupled Receptors (GPCRs). No experimental structural data of any OR is available to date and atomic-level insights are likely to be obtained by means of molecular modeling. In this article, we critically align sequences of ORs with those GPCRs for which a structure is available. Here, an alignment consistent with available site-directed mutagenesis data on various ORs is proposed. Using this alignment, the choice of the template is deemed rather minor for identifying residues that constitute the wall of the binding cavity or those involved in G-protein recognition.
© 2015 The Protein Society. Manuscript Accepted: 25 May 2015; Manuscript Received: 24 Mar 2015. Accepted manuscript online: 5 Jun 2015. This work was supported by grants from APEX Region PACA to J. G. (OLFACTOME) and from the Fondation Roudnitska under the aegis of Fondation de France to C.A.D.M.
Accepted Version - de_March_2015.pdf
Supplemental Material - pro2717-sup-0001-suppinfo.docx