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Published April 16, 2020 | metadata_only
Journal Article

Flexible Electrochemical Bioelectronics: The Rise of In Situ Bioanalysis


The amalgamation of flexible electronics in biological systems has shaped the way health and medicine are administered. The growing field of flexible electrochemical bioelectronics enables the in situ quantification of a variety of chemical constituents present in the human body and holds great promise for personalized health monitoring owing to its unique advantages such as inherent wearability, high sensitivity, high selectivity, and low cost. It represents a promising alternative to probe biomarkers in the human body in a simpler method compared to conventional instrumental analytical techniques. Various bioanalytical technologies are employed in flexible electrochemical bioelectronics, including ion‐selective potentiometry, enzymatic amperometry, potential sweep voltammetry, field‐effect transistors, affinity‐based biosensing, as well as biofuel cells. Recent key innovations in flexible electrochemical bioelectronics from electrochemical sensing modalities, materials, systems, fabrication, to applications are summarized and highlighted. The challenges and opportunities in this field moving forward toward future preventive and personalized medicine devices are also discussed.

Additional Information

© 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. Received: April 1, 2019; Revised: April 30, 2019; Published online: August 20, 2019. Y.Y. and H.Y.Y.N contributed equally to this work. This work was supported by the California Institute of Technology, the Rothenberg Innovation Initiative (RI2) program, the Carver Mead New Adventures Fund (to Y.Y. and W.G.), and by NSF Nanomanufacturing Systems for Mobile Computing and Energy Technologies (NASCENT) Center and the Berkeley Sensor and Actuator Center (BSAC) (to H.Y.Y.N. and A.J.). The authors declare no conflict of interest.

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August 22, 2023
August 22, 2023