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Published November 2020 | Accepted Version
Journal Article Open

Spatiotemporal Antialiasing in Photoacoustic Computed Tomography


Photoacoustic computed tomography (PACT) based on a full-ring ultrasonic transducer array is widely used for small animal wholebody and human organ imaging, thanks to its high in-plane resolution and full-view fidelity. However, spatial aliasing in full-ring geometry PACT has not been studied in detail. If the spatial Nyquist criterion is not met, aliasing in spatial sampling causes artifacts in reconstructed images, even when the temporal Nyquist criterion has been satisfied. In this work, we clarified the source of spatial aliasing through spatiotemporal analysis. We demonstrated that the combination of spatial interpolation and temporal filtering can effectively mitigate artifacts caused by aliasing in either image reconstruction or spatial sampling, and we validated this method by both numerical simulations and in vivo experiments.

Additional Information

© 2020 IEEE. Manuscript received April 11, 2020; accepted May 24, 2020. Date of publication May 29, 2020; date of current version October 28, 2020. This work was sponsored by National Institutes of Health Grants R01 CA186567 (NIH Director's Transformative Research Award), R01 NS102213, U01 NS099717 (BRAIN Initiative), and R35 CA220436 (Outstanding Investigator Award). The authors appreciate the close reading of the manuscript by Professor James Ballard. Lihong V. Wang has financial interests in Microphotoacoustics, Inc., CalPACT, LLC, and Union Photoacoustic Technologies, Ltd., which did not support this work.

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Accepted Version - nihms-1641896.pdf


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August 20, 2023
October 20, 2023