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Published July 2009 | public
Journal Article

Preliminary Study on Skin Cancer Detection in Sencar Mice Using Mueller Optical Coherence Tomography


We report on the use of a fiber-based Mueller-matrix optical coherence tomography (OCT) system with continuous source-polarization modulation for in vivo imaging of early stages of skin cancer in SENCAR mice. A homemade hand-held probe with integrated optical scanning and beam delivering optics was coupled in the sample arm. The OCT images show the morphological changes in skin resulting from pre-cancerous papilloma formations that are consistent with histology, thus demonstrating the system's potential for early skin cancer detection.

Additional Information

© 2009 World Scientific Publishing Company. This project was sponsored in part by the Department of the Army (Cooperative Agreement Number: DAMD17-97-2-7016) and the National Institutes of Health (R01 CA092415). The content of the information presented in this paper does not necessarily reflect the position or the policy of the government or NMTB. No official endorsement should be inferred

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August 21, 2023
October 19, 2023