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Published October 10, 2005 | public
Journal Article Open

Thermal management in microfluidics using micro-Peltier junctions


We report refrigeration and heating of nanoliter fluid volumes with micro-Peltier junctions. The temperature of small liquid reservoirs can be rapidly changed and controlled within a range between -3 degrees C to over 120 degrees C with good long-term stability. These thermal management systems enable the fabrication of complex chip-based chemical and biochemical reaction systems in which the temperature of many processes can be controlled independently.

Additional Information

©2005 American Institute of Physics. Received 11 May 2005; accepted 18 August 2005; published online 5 October 2005. The authors would like to thank Dr. Hylan B. Lyon, Jr. and Dr. Jeff W. Sharp from Marlow Industries Incorporated for the thermoelectric coolers and valuable help and advice throughout this project. They also acknowledge funding for this project from the NIH under Grant No. 1 R01 HG002644-01A1.


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