Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published August 2015 | Published
Journal Article Open

In vivo photoacoustic flowmetry at depths of the diffusive regime based on saline injection


We propose a saline injection-based method to quantify blood flow velocity in vivo with acoustic-resolution photoacoustic tomography. By monitoring the saline–blood interface propagating in the blood vessel, the flow velocity can be resolved. We first demonstrated our method in phantom experiments, where a root mean square error of prediction of 0.29  mm/s 0.29  mm/s was achieved. By injecting saline into a mouse tail vein covered with 1 mm chicken tissue, we showed that the flow velocity in the tail vein could be measured at depths, which is especially pertinent to monitoring blood flow velocity in patients undergoing intravenous infusion.

Additional Information

© 2015 SPIE. Paper 150337R received May 18, 2015; accepted for publication Jul. 20, 2015; published online Aug. 12, 2015. The authors would like to thank Professor James Ballard for manuscript editing. This work was sponsored in part by National Institutes of Health grants DP1 EB016986 (NIH Director's Pioneer Award), R01 CA186567 (NIH Director's Transformative Research Award), R01 EB016963, S10 RR026922, and R01 CA159959. L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

Attached Files

Published - JBO_20_8_087001.pdf


Files (1.6 MB)
Name Size Download all
1.6 MB Preview Download

Additional details

August 22, 2023
October 20, 2023