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Sticks and Stones, a conserved cell surface ligand for the Type IIa RPTP Lar, regulates neural circuit wiring in Drosophila
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Introduction
Results
Identification of Sns as a Lar binding partner
Mammalian orthologs of Lar and Sns bind to each other in embryos and in vitro
Lar and Sns are co-expressed in larval motor neurons
Lar and Sns genetically interact to shape morphogenesis of NMJs
Lar and Sns act in cis at the NMJ
Lar and Sns genetically interact to control formation of the larval MB
Expression patterns of Lar and Sns in the pupal and adult MB
Lar and Sns genetically interact to regulate morphogenesis of α/β and α′/β′ lobes of the adult MB
Lar and Sns expression in the pupal and adult OL
Lar and Sns interact to regulate R7 photoreceptor axon targeting
Discussion
Lar and Sns act in cis to regulate NMJ morphogenesis
Trans interactions between Lar and Sns regulate axon guidance of MB KCs
Sns is required in trans for Lar’s roles in R7 photoreceptor axon targeting
Evolutionary conservation of the Lar–Sns interaction
Materials and methods
Drosophila genetics
Immunohistochemistry
Molecular biology
ECIA
Confocal imaging and image analysis
Statistical analysis
Acknowledgements
Additional information
Funding
Author contributions
Author ORCIDs
Decision letter and Author response
Additional files
Supplementary files
References
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