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Published July 2006 | public
Journal Article

Significantly accelerated osteoblast cell growth on aligned TiO_2 nanotubes


Vertically aligned yet laterally spaced nanoscale TiO2 nanotubes have been grown on Ti by anodization, and the growth of MC3T3-E1 osteoblast cells on such nanotubes has been investigated. The adhesion/propagation of the osteoblast is substantially improved by the topography of the TiO_2 nanotubes with the filopodia of growing cells actually going into the nanotube pores, producing an interlocked cell structure. The presence of the nanotube structure induced a significant acceleration in the growth rate of osteoblast cells by as much as ∼300–400%.

Additional Information

© 2006 Wiley Periodicals, Inc. Received 12 August 2005; revised 8 December 2005; accepted 22 December 2005; Published online 6 April 2006. The authors thank J. Blackwell at UC San Diego for helpful discussions and assistance in experiments.

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October 20, 2023