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Published March 2009 | Published
Journal Article Open

Photoacoustic tomography of the mouse cerebral cortex with a high-numerical-aperture-based virtual point detector


The mouse cerebral cortex was imaged in situ by photoacoustic tomography (PAT). Instead of a flat ultrasonic transducer, a virtual point detector based on a high numerical aperture (NA), positively focused transducer was used. This virtual point detector has a wide omnidirectional acceptance angle, a high sensitivity, and a negligible aperture effect. In addition, the virtual point detector can be located much more closely to the object during the detection. Compared with a finite-size flat transducer, images generated by using this virtual point detector have both uniform signal-to-noise ratio (SNR) and resolution.

Additional Information

© 2009 SPIE. Paper 08244R received Jul. 17, 2008; revised manuscript received Feb. 18, 2009; accepted for publication Feb. 26, 2009; published online Apr. 22, 2009. This project was sponsored in part by National Institutes of Health Grant Nos. R01 NS46214(BRP) and R01 EB000712. L.W. has a financial interest in Endra, Inc., which, however, did not support this work.

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