eLife Sciences Publications, Ltd is a limited liability non
-
profit non
-
stock corporation incorporated in the State of
Delaware, USA, with company number 5030732, and is registered in the UK with
company number FC030576 and
branch number BR015634 at the address
1st Floor, 24 Hills Road, Cambridge CB2 1JP | August 2014
1
eLife
’s
transparent reporting
form
We encourage authors to provide detailed information
within their submission
to facilitate
the interpretation and replication of experiments.
A
uthors
can
upload supporting
documentation to indicate the use of appropriate reporting guidelines for health
-
related
research (see
EQUATOR Network
), life science research (see the
BioSharing Information
Resource
), or the
ARRIVE guidelines
for reporting work involving animal research
.
Whe
re
applicable, a
uthors
should
refer to
any relevant reporting standards
documents in
th
is
form.
If you have any questions, please
consult our
Journal Policies
and/or
contact us:
editorial@elifesciences.org
.
Sample
-
size estimation
•
Y
ou
should state
whether an appropriate sample size was computed when the
study was being designed
•
You should
state
the sta
tistical method of
sample size
computation
and any
required assumptions
•
If no
explicit
power analysis was used, you
should describe how you
decide
d
what
sample
(replicate)
size
(number) to use
Please outline where this information can be found within the submission (e.g.,
sections
or
figure legends), or explain why this informatio
n doesn’t apply to your submission:
Replicates
•
You should
report how often each experiment was performed
•
You should include
a
definition of biological versus technical replicat
ion
•
The data obtained should be provided and sufficient information should be
provided to indicate the number of independent biological and/or technical
replicates
•
If you
encountered any outliers
, you should describe
how
these
were
handled
•
Criteria for exclusion/inclusion of data should be clearly stated
•
High
-
throughput sequence dat
a
should be
upload
ed
before submission,
with a
private
link
for
reviewer
s provided
(
these are available from both GEO and
ArrayExpress
)
Please
outline
where this information
can
be found within the submission (e.g.,
sections
or
figure legend
s
), or explain
why this information doesn’t apply to your submission:
eLife Sciences Publications, Ltd is a limited liability non
-
profit non
-
stock corporation incorporated in the State of
Delaware, USA, with company number 5030732, and is registered in the UK with
company number FC030576 and
branch number BR015634 at the address
1st Floor, 24 Hills Road, Cambridge CB2 1JP | August 2014
2
Statistical reporting
•
S
tatistic
al analysis methods
should be descr
ibed and justified
•
Raw data should be presented in figures whenever informative to do so (typicall
y
when N per group
is
less than
10)
•
F
or each experiment
,
you should
identify
the statistical test
s
used, exact value
s
of
N, definition
s
of center, method
s
of multiple test correction, and dispersion and
precision measures (e.g., mean
,
median
,
SD
,
SEM
,
confidence intervals
;
and,
for the
m
ajor substantive results,
a measure of effect size (e.g., Pearson's r, Cohen's d
)
•
Report exact p
-
values wherever possible alongside the summary statistics and 95%
confidence intervals. These should be reported for all key questions and not
only
when the
p
-
value is less than 0.05.
Please
outline
where this information
can
be found within the submission (e.g.,
sections
or
figure legend
s
)
, or explain why this information doesn’t apply to your submission
:
(F
or large datasets, or papers with a very large nu
mber of statistical tests, you
may
upload a
single table file with tests, Ns
,
etc.
,
with
reference to s
ections
in
the
manuscript
.
)
Group allocation
•
Indicate how samples were allocated into experimental groups (in
the
case of
clinical studies, please
specify allocation to treatment method)
;
i
f randomization
was used, please also
state if restricted randomization was
applied
•
Indicate if masking was used during group allocation, data collection and/or data
analysis
Please outline where this information can be found within the submission (e.g.,
sections or
figure legends
), or explain why this information doesn’t apply to your submission:
A
dditional data files (
“source data”
)
•
We encourage you to upload
relevant additional data files
, such as
numerical
data
that
are represented as a
graph
in a figure,
or
as a
summary table
•
Where provided, these should be in the most useful format, and they can be
uploaded as “Source data” files linked to
a main figure
or
table
•
Include model definition files including
the
full list of
parameters used
•
Include
code
used for data analysis
(e.g., R, MatLab)
•
Avoid
stat
ing
that data files are
“available
upon request”
Please indicate the figures or tables for which source data f
iles have been provided: