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Published January 1981 | Published
Journal Article Open

Replacement of riboflavin by an analogue in the blue-light photoreceptor of Phycomyces


Under suitable conditions, roseoflavin [7-methyl-8-dimethylamino-10-(1'-D-ribityl)isoalloxazine] replaces riboflavin to about 80% in the photoreceptor of Phycomyces. The substitute-bearing photoreceptor functions with an efficiency of about 0.1% of that of the normal receptor. The substitution is proven by (i) a decrease of the effective light flux by a factor of 4.7, expressed as a corresponding increase in threshold, and (ii) an increase of the effectiveness of 529-nm light relative to 380-nm light. It has also been shown that roseoflavin is taken up by the mycelium, translocated to the sporangiophore, and effectively phosphorylated by the riboflavin kinase of Phycomyces.

Additional Information

© 1981 by the National Academy of Sciences. Contributed by Max Delbrück, September 12, 1980. The research was supported by National Science Foundation Grant PCM 76-15164 and by a fellowship from the Deutsche Forschungsgemeinschaft to M.K.O. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.

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