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Published February 2011 | Published
Journal Article Open

In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry


In this letter, we report the first use of oblique incidence diffuse reflectance spectrometry to conduct in-vivo measurements of optical properties of three different types of pigmented skin lesions, including melanoma, dysplastic, and common nevi. Both absorption and reduced scattering coefficient spectra were estimated from the spatially resolved diffuse reflectance within the wavelength range of 455–765 nm for 144 pigmented skin lesions including 16 melanomas. The absorption and reduced scattering spectra were found to change with the malignancy of the skin lesions, which were generally higher for the malignant cases than the benign ones. Based on the measurement results, the physiological origin leading to the change of the absorption and scattering properties is also discussed.

Additional Information

© 2011 SPIE. Paper 10556LR received Oct. 12, 2010; revised manuscript received Dec. 16, 2010; accepted for publication Dec. 16, 2010; published online Feb. 17, 2011. The authors thank Dr. Mays, Dr. Hymens, and Dr. Mansfield and the staff from the Melanoma and Skin Center at the University of Texas M. D. Anderson Cancer Center for their help during the data collection. This project is sponsored by the National Institute of Health through Grant No. R01 CA106728.

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