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Published January 2011 | public
Book Section - Chapter

Ultrathin parylene-C semipermeable membranes for biomedical applications


We report here an in-depth study of the permeability of ultrathin parylene-C (0.15-0.80 μm thick) by measuring the diffusion coefficients of FITC-dextran molecules with different molecular weights (MW). As a validation, we have successfully demonstrated the application of the ultrathin semipermeable membranes in perfusion cancer cell culture. The results show that, with a combined biocompatibility and good permeability, ultrathin parylene-C can be a promising semipermeable membrane material for biomedical applications.

Additional Information

© 2011 IEEE. This work is supported by CIRM, the California Institute for Regenerative Medicine, through USC. The authors would like to thank Dr. Danhong Zhu and Jing Xu from Dr. David Hinton's Lab in Doheny Eye Institute of USC for thei assistance and helpful discussion. PC-3 cancer cells were generously provided by Dr. Amir Goldkorn's Lab in the Norris Cancer Center of USC.

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