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Published December 2007 | Published
Journal Article Open

Deep reflection-mode photoacoustic imaging of biological tissue


A reflection-mode photoacoustic (PA) imaging system was designed and built to image deep structures in biological tissues. We chose near-infrared laser pulses of 804-nm wavelength for PA excitation to achieve deep penetration. To minimize unwanted surface signals, we adopted dark-field ring-shaped illumination. This imaging system employing a 5-MHz spherically focused ultrasonic transducer provides penetration up to 38mm in chicken breast tissue. At the 19-mm depth, the axial resolution is 144μm and the transverse resolution is 560μm. Internal organs of small animals were imaged clearly.

Additional Information

© 2007 SPIE. Paper 07167LR received May 13, 2007; revised manuscript received Sep. 11, 2007; accepted for publication Sep. 12, 2007; published online Dec. 11, 2007. We are grateful to Konstantin Maslov and Xinmai Yang for experimental assistance. This research is sponsored in part by National Institutes of Health Grant Nos. R01 EB000712 and R01 NS46214 (BRP).

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