The study of quantitative optical absorption imaging by using Monte Carlo simulation of combined photoacoustic tomography and ultrasound-modulated optical tomography
We demonstrate the feasibility of quantitative optical absorption imaging by using Monte Carlo simulation of combined photoacoustic tomography (PAT) and ultrasound-modulated optical tomography (UOT). Our simulation results show that the optical fluence on initial photoacoustic (PA) pressure waves can be accurately compensated for recovering exact optical absorption coefficients by using a fluence map acquired from UOT signals. Further, when the optical heterogeneities of a sample were varied, the recovered optical absorption coefficients from a target remained constant while PA amplitudes fluctuated. In practice, PAT and UOT systems can be potentially combined because both imaging systems can easily share light illumination and ultrasound application patterns.
Additional Information© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was supported by the University at Buffalo Research Foundation faculty start-up fund.
Published - 82232C.pdf