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Published December 2010 | Accepted Version
Journal Article Open

A Facile Synthesis of Novel Self-Assembled Gold Nanorods Designed for Near-Infrared Imaging


Molecular imaging techniques now allow recognition of early biochemical, physiological, and anatomical changes before manifestation of gross pathological changes. Photoacoustic imaging represents a novel non-ionizing detection technique that combines the advantages of optical and ultrasound imaging. Noninvasive photoacoustic tomography (PAT) imaging in combination with nanoparticle-based contrast agents show promise in improved detection and diagnosis of cardiovascular and cancer related diseases. In this report, a novel strategy is introduced to achieve self-assembled colloidal gold nanorods, which are constrained to the vasculature. Gold nanorods (2–4 nm) were incorporated into the core of self-assembled lipid-encapsulated nanoparticles (sGNR) (∼130 nm), providing more than hundreds of gold atoms per nanoparticle of 20% colloid suspension. The physico-chemical characterization in solution and anhydrous state with analytical techniques demonstrated that the particles were spherical and highly mono dispersed. In addition to the synthesis and characterization, sensitive near-infrared photoacoustic detection was impressively demonstrated in vitro.

Additional Information

© 2010 American Scientific Publishers. The financial support from the AHA under grant number 0835426N (Dipanjan Pan), from NIH under grant numbers NS059302, CA119342 (Gregory M. Lanza), HL073646 (Samuel A. Wickline), U54 CA136398, R01EB000712, R01NS046214, EB008085 (Lihong V. Wang) is greatly appreciated. Lihong V. Wang has a financial interest in Microphotoacoustic, Inc. and Endra, Inc., which, however, did not support this work.

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Accepted Version - nihms282658.pdf


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