Distinct Intracellular Trafficking Patterns of Host IgG by Herpes Virus Fc-Receptors
Members of both alpha and beta herpes viruses affects 50–98% of people around the world. They cause severe symptoms in congenitally infected newborns, a lifelong latent infection that is lethal in immuno-compromised individuals, and are associated with several types of cancer. Human cytomegalovirus (HCMV) and herpes simplex virus type 1 (HSV-1) viruses express proteins (HCMV gp68 and gp34; HSV-1 gE-gI) that function as Fcγ receptors (FcγRs) by binding to the Fc regions of human IgG. In addition to binding free IgG, these viral FcγRs can bind to IgG complexed with an antigen to form an antibody bipolar bridged (ABB) complex. The effects of Fcγ binding by these viral molecules are poorly understood.
© 2015 Federation of American Societies for Experimental Biology.