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Published August 15, 2006 | Published
Journal Article Open

In vivo three-dimensional photoacoustic tomography of a whole mouse head


An in vivo photoacoustic imaging system was designed and implemented to image the entire small animal head. A special scanning gantry was designed to enable in vivo imaging in coronal cross sections with high contrast and good spatial resolution for the first time to our knowledge. By use of a 2.25 MHz ultrasonic transducer with a 6 mm diameter active element, an in-plane radial resolution of ∼312  µm was achieved. Deeply seated arterial and venous vessels in the head measuring up to 1.7 cm in diameter were simultaneously imaged in vivo with 804 nm wavelength laser excitation of photoacoustic waves.

Additional Information

© 2006 Optical Society of America. Received April 4, 2006; revised May 15, 2006; accepted May 17, 2006; posted May 26, 2006 (Doc. ID 69679); published July 25, 2006. We thank Jung-Taek Oh, Meng-Lin Li, Konstantin Maslov, Geng Ku, and Xueyi Xie for technical assistance and Sergiu V. Similache for assistance with animal handling. The project was sponsored by National Institutes of Health grants R01 EB000712 and R01 NS46214.

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