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Published July 27, 2018 | Supplemental Material + Published
Journal Article Open

Short Enantioselective Formal Synthesis of (–)-Platencin


A short enantioselective formal synthesis of the antibiotic natural product platencin is reported. Key steps in the synthesis include enantioselective decarboxylation alkylation, aldehyde/olefin radical cyclization, and regioselective aldol cyclization.

Additional Information

© 2018 Georg Thieme Verlag Stuttgart. Dedicated to Prof. Dr. Scott E. Denmark on the occasion of his 65th birthday. We thank the NIH-NIGMS (R01 GM080269), DAAD (postdoctoral fellowship to C.D.), Eli Lilly (predoctoral fellowship to J.T.M.), Amgen, Bristol-Myers Squibb, Merck Research Laboratories, Abbott Laboratories, Boehringer-Ingelheim, and Caltech for generous funding. We also thank the UIC Department of Chemistry (startup funds to J.T.M.) and the National Science Foundation (CAREER Award 1654490 to J.T.M.). We thank Dr. Michael W. Day and Larry Henling for crystallographic analysis.

Attached Files

Published - s-0037-1610437.pdf

Supplemental Material - sup_ss-2018-c0304-op_10-1055_s-0037-1610437.pdf


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August 19, 2023
October 18, 2023