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Published November 1995 | Published
Journal Article Open

The influence of boundary conditions on the accuracy of diffusion theory in time-resolved reflectance spectroscopy of biological tissues


The applicability of diffusion theory for the determination of tissue optical properties from time-resolved reflectance spectroscopy is investigated. Analytical expressions from diffusion theory using the three most commonly assumed boundary conditions at the air-tissue interface are compared with time-resolved Monte Carlo simulations and measurements on tissue phantoms. The effects of the choice of the boundary conditions on the accuracy of the findings for the optical parameters are quantified, and criteria for accurate curve-fitting algorithms are developed.

Additional Information

© 1995 IOP Publishing Ltd. Received 30 January 1995, in final form 30 June 1995. The authors would like to thank Dr H Liu and Professor B Chance from the Department of Biochemistry and Biophysics at the University of Pennsylvania for support in the experimental set-up and the careful review of the paper. Furthermore the help of D Boas with the calculation of the scattering coefficient of the polystyrene sphere solutions is appreciated. This work was supported by the Robert A Welch Foundation, the Department of Energy, and NIH (R29-HL45045).

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