<ROSETTASCRIPTS> <SCOREFXNS> <ScoreFunction name="scorefxn_full" weights="ref2015" symmetric="1"> <Reweight scoretype="coordinate_constraint" weight="0.1"/> </ScoreFunction> <ScoreFunction name="soft_rep_full" weights="soft_rep" symmetric="1"> <Reweight scoretype="coordinate_constraint" weight="0.1"/> <Reweight scoretype="res_type_constraint" weight="0"/> </ScoreFunction> </SCOREFXNS> <RESIDUE_SELECTORS> <Index name="ress_fix" resnums="101A,103A,116A,156A,154A,72A,121A,68A,56A,63A,66A,1X"/> </RESIDUE_SELECTORS> <TASKOPERATIONS> <RestrictToRepacking name="rtr"/> <OperateOnResidueSubset name="fix_not_neighbor"> <Not> <Neighborhood distance="8"> <Index resnums="53A,64A,67A,73A,87A,91A,92A,99A,112A,118A,129A,134A,141A"/> </Neighborhood> </Not> <PreventRepackingRLT/> </OperateOnResidueSubset> <InitializeFromCommandline name="init"/> <IncludeCurrent name="include_curr"/> <OperateOnResidueSubset name="fix_res" selector="ress_fix"> <PreventRepackingRLT/> </OperateOnResidueSubset> <OperateOnResidueSubset name="not_to_cst_sc"> <Not selector="ress_fix"/> <PreventRepackingRLT/> </OperateOnResidueSubset> </TASKOPERATIONS> <FILTERS> <DesignableResidues name="designable" task_operations="fix_not_neighbor" designable="0" packable="1"/> </FILTERS> <MOVERS> <SetupForSymmetry name="setup_symm" definition="5k21.sym"/> <MutateResidue name="mutres0" new_res="%%new_res0%%" target="%%target0%%" preserve_atom_coords="%%pac0%%"/> <MutateResidue name="mutres1" new_res="%%new_res1%%" target="%%target1%%" preserve_atom_coords="%%pac1%%"/> <MutateResidue name="mutres2" new_res="%%new_res2%%" target="%%target2%%" preserve_atom_coords="%%pac2%%"/> <MutateResidue name="mutres3" new_res="%%new_res3%%" target="%%target3%%" preserve_atom_coords="%%pac3%%"/> <MutateResidue name="mutres4" new_res="%%new_res4%%" target="%%target4%%" preserve_atom_coords="%%pac4%%"/> <MutateResidue name="mutres5" new_res="%%new_res5%%" target="%%target5%%" preserve_atom_coords="%%pac5%%"/> <MutateResidue name="mutres6" new_res="%%new_res6%%" target="%%target6%%" preserve_atom_coords="%%pac6%%"/> <MutateResidue name="mutres7" new_res="%%new_res7%%" target="%%target7%%" preserve_atom_coords="%%pac7%%"/> <MutateResidue name="mutres8" new_res="%%new_res8%%" target="%%target8%%" preserve_atom_coords="%%pac8%%"/> <MutateResidue name="mutres9" new_res="%%new_res9%%" target="%%target9%%" preserve_atom_coords="%%pac9%%"/> <MutateResidue name="mutres10" new_res="%%new_res10%%" target="%%target10%%" preserve_atom_coords="%%pac10%%"/> <MutateResidue name="mutres11" new_res="%%new_res11%%" target="%%target11%%" preserve_atom_coords="%%pac11%%"/> <MutateResidue name="mutres12" new_res="%%new_res12%%" target="%%target12%%" preserve_atom_coords="%%pac12%%"/> <ConstraintSetMover name="add_CA_cst" cst_file="5k21.cst"/> <AtomCoordinateCstMover name="fix_res_sc_cst" coord_dev="0.5" bounded="false" sidechain="true" task_operations="not_to_cst_sc"/> <SymPackRotamersMover name="prm" task_operations="init,include_curr,rtr,fix_not_neighbor,fix_res" scorefxn="scorefxn_full"/> <SymMinMover name="min" bb="1" chi="1" jump="0" scorefxn="scorefxn_full"/> <SymPackRotamersMover name="soft_repack" scorefxn="soft_rep_full" task_operations="init,include_curr,rtr,fix_not_neighbor,fix_res"/> </MOVERS> <PROTOCOLS> <Add mover_name="setup_symm"/> <Add mover="add_CA_cst"/> <Add mover="fix_res_sc_cst"/> <Add mover="mutres0"/> <Add mover="mutres1"/> <Add mover="mutres2"/> <Add mover="mutres3"/> <Add mover="mutres4"/> <Add mover="mutres5"/> <Add mover="mutres6"/> <Add mover="mutres7"/> <Add mover="mutres8"/> <Add mover="mutres9"/> <Add mover="mutres10"/> <Add mover="mutres11"/> <Add mover="mutres12"/> <Add mover="soft_repack"/> <Add mover="min"/> <Add mover="prm"/> <Add mover="min"/> <Add filter="designable"/> </PROTOCOLS> <OUTPUT scorefxn="scorefxn_full"/> </ROSETTASCRIPTS>