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Published July 2001 | Published
Journal Article Open

Signal processing in scanning thermoacoustic tomography in biological tissues


Microwave-induced thermoacoustic tomography was explored to image biological tissues. Short microwave pulses irradiated tissues to generate acoustic waves by thermoelastic expansion. The microwave-induced thermoacoustic waves were detected with a focused ultrasonic transducer to obtain two-dimensional tomographic images of biological tissues. The dependence of the axial and the lateral resolutions on the spectra of the signals was studied. A reshaping filter was applied to the temporal piezoelectric signals from the transducer to increase the weight of the high-frequency components, which improved the lateral resolution, and to broaden the spectrum of the signal, which enhanced the axial resolution. A numerical simulation validated our signal-processing approach.

Additional Information

© 2001 American Association of Physicists in Medicine. Received 12 December 2000; accepted for publication 27 March 2001. We thank G. Ku for experimental assistance. This project was sponsored in part by the U.S. Army Medical Research and Materiel Command Grant No. DAMD17-00-1-0455, the National Institutes of Health Grants No. R01 CA71980 and No. R21 CA83760, the National Science Foundation Grant No. BES-9734491, and Texas Higher Education Coordinating Board Grant No. ARP 000512-0123-1999.

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