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Published January 18, 1980 | public
Journal Article

Vesicle Targeting: Timed Release and Specificity for Leukocytes in Mice by Subcutaneous Injection


When unilamellar vesicles were administered subcutaneously in mice, the half-time for the destruction of the vesicles varied from 12 to 600 hours, depending on their composition. The vesicles tested consisted of distearoyl phosphatidylcholine, cholesterol, and certain sugar and amino-sugar derivatives of cholesterol. Vesicles with amino-sugar derivatives showed the greatest longevity and became localized with high specificity in aggregates of polymorphonuclear leukocytes. A substantial delay between the time that the vesicles broke open and the time that labels contained in the vesicles were excreted suggests that the vesicles undergo endocytosis before destruction.

Additional Information

© 1980 American Association for the Advancement of Science. 13 August 1979; revised 25 October 1979. We thank T. Y. Shen and M. M. Ponpipom (Merck Sharp & Dohme Research Laboratories) for valuable discussion during this work. We also thank R. L. Teplitz (City of Hope) for providing anatomical and cytological identifications. This investigation was supported by NIH grant GM 21111-06, NSF grant CHE75-15146 A04, and Merck & Co., Inc. This is contribution No. 6014 from the Arthur Amos Noyes Laboratory of Chemical Physics.

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