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Published April 2011 | Supplemental Material + Published + Accepted Version
Journal Article Open

Gold nanocages covered with thermally-responsive polymers for controlled release by high-intensity focused ultrasound


This paper describes the use of Au nanocages covered with smart, thermally-responsive polymers for controlled release with high-intensity focused ultrasound (HIFU). HIFU is a highly precise medical procedure that uses focused ultrasound to heat and destroy pathogenic tissue rapidly and locally in a non-invasive or minimally invasive manner. The released dosage could be remotely controlled by manipulating the power of HIFU and/or the duration of exposure. We demonstrated localized release within the focal volume of HIFU by using gelatin phantom samples containing dye-loaded Au nanocages. By placing chicken breast tissues on top of the phantoms, we further demonstrated the feasibility of this system for controlled release at depths up to 30 mm. Because it can penetrate more deeply into soft tissues than near-infrared light, HIFU is a potentially more effective external stimulus for rapid, on-demand drug release.

Additional Information

© 2011 The Royal Society of Chemistry. Received 1st December 2010, Accepted 3rd January 2011, First published online 14 Feb 2011. This work was supported in part by a 2006 NIH Director's Pioneer Award (DP1 OD000798) and startup funds from Washington University in St Louis (to X.Y.). This work was also sponsored by NIH grants (No. R01 EB000712, No. R01 EB008085, No. R01 CA134539, and No. U54 CA136398, to L.V.W). Part of the research was performed at the Nano Research Facility (NRF), a member of the National Nanotechnology Infrastructure Network (NNIN), which is supported by the NSF under ECS-0335765. L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

Attached Files

Published - C0NR00932F.pdf

Accepted Version - nihms-263082.pdf

Supplemental Material - c0nr00932f_si.pdf


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