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Published 2009 | Published
Journal Article Open

Genomic control of patterning


The development of multicellular organisms involves the partitioning of the organism into territories of cells of specific structure and function. The information for spatial patterning processes is directly encoded in the genome. The genome determines its own usage depending on stage and position, by means of interactions that constitute gene regulatory networks (GRNs). The GRN driving endomesoderm development in sea urchin embryos illustrates different regulatory strategies by which developmental programs are initiated, orchestrated, stabilized or excluded to define the pattern of specified territories in the developing embryo.

Additional Information

© 2009 UBC Press. Published online: 5 March 2009. We thank Andrew Ransick for helpul discussion and critical reading of the manuscript. Research was funded by NIH grant HD37105; I.P. was supported by a fellowship from the Swiss National Science Foundation.

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August 20, 2023
October 19, 2023