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Published 1984 | public
Journal Article

The ubiquitin-mediated proteolytic pathway and mechanisms of energy‐dependent intracellular protein degradation


In this review we briefly describe the lysosomal system, consider the evidence for multiplicity of protein degradation pathways in vivo, discuss in detail the ubiquitin‐mediated pathway of intracellular ATP‐dependent protein degradation, and also the possible significance of ubiquitin‐histone conjugates in chromatin. For detailed discussions of the various characteristics and physiological roles of intracellular protein breakdown, the reader is referred to earlier reviews [1–7] and reports of recent symposia [8–10]. Information on the ubiquitin system prior to 1981 was described in an earlier review [11]. Hershko has briefly reviewed more recent information [12].

Additional Information

© 1984 Alan R. Liss, Inc. Manuscript accepted: 25 October 1983; Manuscript revised: 25 October 1983; Manuscript received: 13 June 1983.

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August 22, 2023
October 23, 2023