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Published March 6, 2006 | Published
Book Section - Chapter Open

Functional photoacoustic microscopy in vivo


Functional photoacoustic microscopy is a hybrid imaging technique that detects laser induced photoacoustic waves to image biological tissues in three dimensions. Its imaging depth exceeds the fundamental depth limit of the existing high resolution optical imaging modalities while maintaining a comparable ratio of imaging depth to axial resolution. The amplitude of photoacoutic waves is related to tissue's optical absorption and, therefore, functional imaging can be achieved by acquiring spectroscopic information. We demonstrate here the capabilities of functional photoacoustic microscopy by volumetric imaging a skin melanoma tumor and functional imaging of hemoglobin oxygen saturation in single vessels in vivo.

Additional Information

© 2006 Society of Photo-optical Instrumentation Engineers (SPIE). We thank Ovidiu Craciun, Geng Ku, Meng-lin Li, and Gina Lungu for experimental assistance. This project is sponsored by National Institutes of Health grants R01 EB000712 and R01 NS46214.

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