CaltechAUTHORS
Published March 1999 | Version public
Journal Article Metadata-only

Tandem Hairpin Motif for Recognition in the Minor Groove of DNA by Pyrrole–Imidazole Polyamides

Creators

Abstract

Linking hairpin recognition units "tail-to-turn" in the minor groove of DNA results in the extension of hairpin polyamide binding site size to 11 base pairs. A twelve-ring tandem hairpin (see diagram) binds its match DNA site at picomolar concentrations with unprecedented sequence specificity.

Additional Information

© 1999 Wiley-VCH Verlag GmbH, D-69451 Weinheim. Received: August 31, 1998. First published: 24 February 1999. We are grateful to the National Institutes of Health (GM-27681) for research support, the National Institutes of Health for a research service award to D.M.H., and the Howard Hughes Medical Institute for a predoctoral fellowship to E.E.B. We thank G.M. Hathaway for MALDITOF mass spectrometry.

Additional details

Identifiers

Eprint ID
66854
DOI
10.1002/(SICI)1521-3765(19990301)5:3<975::AID-CHEM975>3.0.CO;2-T
Resolver ID
CaltechAUTHORS:20160510-092252491

Related works

Describes
10.1002/(SICI)1521-3765(19990301)5:3<975::AID-CHEM975>3.0.CO;2-T (DOI)

Funding

NIH
GM-27681
Howard Hughes Medical Institute (HHMI)
NIH Predoctoral Fellowship

Dates

Created
2016-05-10
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Updated
2021-11-11
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