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Published March 15, 2007 | Published
Journal Article Open

Photorefractive detection of tissue optical and mechanical properties by ultrasound modulated optical tomography


Ultrasound-modulated optical tomography is a developing hybrid imaging modality that combines high optical contrast and good ultrasonic resolution for imaging soft biological tissue. We developed a photorefractive-crystal-based, time-resolved detection scheme with the use of a millisecond long ultrasound burst to image both the optical and the mechanical properties of biological tissues, with improved detection efficiency of ultrasound-tagged photons.

Additional Information

© 2007 Optical Society of America. Received September 11, 2006; revised November 17, 2006; accepted December 12, 2006; posted December 15, 2006 (Doc. ID 74954); published February 15, 2007. We thank Sava Sakadžić and Roger Zemp for fruitful scientific discussions. This research was supported by the National Institutes of Health grant R33 CA 094267 and Air Force Office of Scientific Research grant FA9550-04-1-0247.

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