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Published April 20, 2005 | Supplemental Material
Journal Article Open

The Direct Acyl-Alkylation of Arynes


An efficient and mild acyl-alkylation of arynes is described. The method is used to synthesize medium-sized carbocycles by the ring-expansion of cyclic β-ketoesters.

Additional Information

© 2005 American Chemical Society. Received 9 February 2005. Published online 26 March 2005. Published in print 1 April 2005. This work is dedicated to our friend and colleague Professor John D. Roberts, the father of benzyne.8 We are grateful to the NDSEG (predoctoral fellowship to U.K.T.), the A. P. Sloan Foundation, the Research Corporation, Pfizer, Novartis, Merck, Amgen, Lilly, Roche, Abbott, AstraZeneka, GlaxoSmithKline, and Caltech for financial support.

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