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Published September 8, 2004 | Supplemental Material
Journal Article Open

A Synthetic DNA Walker for Molecular Transport


Inspired by kinesin movement along a microtubule, we demonstrate a processive bipedal DNA walker. Powered by externally controlled DNA fuel strands, the walker locomotes with a 5 nm stride by advancing the trailing foot to the lead at each step. Real-time monitoring of specific bidirectional walker movement is achieved via multiplexed fluorescence quenching.

Additional Information

© 2004 American Chemical Society. Received April 27, 2004; Publication Date (Web): August 17, 2004. We thank the Winfree laboratory at Caltech for the use of their fluorescent gel scanner. The following research support is gratefully acknowledged:  DARPA and the Air Force Research Laboratory under agreement F30602-01-2-0561, the Ralph M. Parsons Foundation, and the Charles Lee Powell Foundation.

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