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Published September 16, 2011 | public
Journal Article

Engineering Biological Systems with Synthetic RNA Molecules


RNA molecules play diverse functional roles in natural biological systems. There has been growing interest in designing synthetic RNA counterparts for programming biological function. The design of synthetic RNA molecules that exhibit diverse activities, including sensing, regulatory, information processing, and scaffolding activities, has highlighted the advantages of RNA as a programmable design substrate. Recent advances in implementing these engineered RNA molecules as key control elements in synthetic genetic networks are highlighting the functional relevance of this class of synthetic elements in programming cellular behaviors.

Additional Information

© 2011 Elsevier Inc. Available online 15 September 2011. C.D.S. is funded by the National Institutes of Health, National Science Foundation (NSF), and Defense Advanced Research Projects Agency. R.J.B. receives funding through a NSF graduate fellowship.

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August 19, 2023
October 24, 2023