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Published May 25, 2009 | Supplemental Material + Accepted Version
Journal Article Open

Molecular Photoacoustic Tomography with Colloidal Nanobeacons


Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.

Additional Information

© 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: December 5, 2008; Revised: March 6, 2009; Published online: May 5, 2009. Funded by: AHA Grant Number: 0835426N; NIH Grant Numbers: NS059302, CA119342, HL073646, U54 CA136398, R01EB000712, R01NS046214, EB008085.

Attached Files

Accepted Version - nihms148801.pdf

Supplemental Material - anie_200805947_sm_miscellaneous_information.pdf


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