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Published November 14, 2001 | public
Journal Article Open

Tandem Catalysis: The Sequential Mediation of Olefin Metathesis, Hydrogenation, and Hydrogen Transfer with Single-Component Ru Complexes


Organometallic catalysts are traditionally designed and optimized to mediate a single reaction. However, the increasing demand for expedient and efficient synthetic processes requires the development of organometallic reagents that are capable of catalyzing multiple, mechanistically distinct reactions directly or by simple modification. While the Ru complex (PCy_3)_2Cl_2Ru= CHPh (1) has found extensive use in olefin metathesis, it was also recently shown to be an effective precatalyst for mediating radical additions and hydrogenation reactions. We recently demonstrated all three reactions could be performed in tandem to afford well-defined block copolymers. Herein, we report that complex 1, or its more active derivative 2, is also useful in mediating a variety of other catalytic hydrogenation reactions that include regiospecific ketone and olefin reductions, transfer hydrogenations of ketones, and dehydrogenative oxidations of alcohols. In addition, we demonstrate a variety of "one-pot" tandem metathesis-hydrogenation procedures for the rapid construction of small molecules, including (R)-(-)-Muscone.

Additional Information

© 2001 American Chemical Society. Received June 15, 2001; Revised Manuscript Received September 26, 2001; Publication Date (Web): October 17, 2001. The support of the National Institute of Health (NIH) is acknowledged. J.L. is grateful to the NIH for a postdoctoral fellowship. C.B. is grateful to the ACS Division of Organic Chemistry (sponsored by Rohm and Haas) and the National Science Foundation for fellowship support.

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Supplemental Material - ja016431e_s1.pdf

Supplemental Material - ja016431e_s2.pdf


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August 19, 2023
August 19, 2023