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Published July 2014 | Accepted Version
Journal Article Open

Photoacoustic Microscopy and Computed Tomography: From Bench to Bedside


Photoacoustic imaging (PAI) of biological tissue has seen immense growth in the past decade, providing unprecedented spatial resolution and functional information at depths in the optical diffusive regime. PAI uniquely combines the advantages of optical excitation and those of acoustic detection. The hybrid imaging modality features high sensitivity to optical absorption and wide scalability of spatial resolution with the desired imaging depth. Here we first summarize the fundamental principles underpinning the technology, then highlight its practical implementation, and finally discuss recent advances toward clinical translation.

Additional Information

© 2014 Annual Reviews. First published online as a Review in Advance on May 28, 2014. We thank Yan Liu and Sandra Matteucci for close reading of the manuscript. This work was sponsored by the National Institutes of Health (NIH) under grants R01 EB008085, R01 EB016963, R01 CA134539, U54 CA136398, R01 CA157277, R01 CA159959, and DP1 EB016986 (NIH Director's Pioneer Award). L. V. Wang has a financial interest in Microphotoacoustics, Inc. and Endra, Inc.; however, neither provided support for this work. Disclosure Statement: L.V.W. has a financial interest in Microphotoacoustics, Inc., and Endra, Inc.; however, neither provided support for this work.

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Accepted Version - nihms536272.pdf


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