Published October 1997
| public
Journal Article
The ubiquitin system
- Creators
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Varshavsky, Alexander
Abstract
Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to a variety of intracellular proteins that bear degradation signals recognized by this system. The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes, including cell differentiation, the cell cycle and responses to stress.
Additional Information
© 1997 Elsevier. I thank D. Finley, S. Jentsch, and K. Madura for helpful discussions, and G. Turner, L. Peck and A. Webster for comments on the manuscript.Additional details
- Eprint ID
- 108024
- DOI
- 10.1016/s0968-0004(97)01122-5
- Resolver ID
- CaltechAUTHORS:20210211-162600310
- Created
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2021-02-12Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field