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Published October 1997 | public
Journal Article

The ubiquitin system


Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to a variety of intracellular proteins that bear degradation signals recognized by this system. The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes, including cell differentiation, the cell cycle and responses to stress.

Additional Information

© 1997 Elsevier. I thank D. Finley, S. Jentsch, and K. Madura for helpful discussions, and G. Turner, L. Peck and A. Webster for comments on the manuscript.

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October 23, 2023