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Published June 16, 2021 | Published
Journal Article Open

Recent Advances in Photoacoustic Tomography


Photoacoustic tomography (PAT) that integrates the molecular contrast of optical imaging with the high spatial resolution of ultrasound imaging in deep tissue has widespread applications in basic biological science, preclinical research, and clinical trials. Recently, tremendous progress has been made in PAT regarding technical innovations, preclinical applications, and clinical translations. Here, we selectively review the recent progresses and advances in PAT, including the development of advanced PAT systems for small-animal and human imaging, newly engineered optical probes for molecular imaging, broad-spectrum PAT for label-free imaging of biological tissues, high-throughput snapshot photoacoustic topography, and integration of machine learning for image reconstruction and processing. We envision that PAT will have further technical developments and more impactful applications in biomedicine.

Additional Information

© 2021 Lei Li and Lihong V. Wang. Exclusive Licensee Suzhou Institute of Biomedical Engineering and Technology, CAS. Distributed under a Creative Commons Attribution License (CC BY 4.0). Received 31 December 2020; Accepted 29 April 2021; Published 16 June 2021. This work was supported in part by National Institutes of Health grants R01 NS102213, U01 NS099717 (BRAIN Initiative), R35 CA220436 (Outstanding Investigator Award), R01 EB028277, and U01 EB029823 (BRAIN Initiative). Conflicts of Interest. L.V.W. has financial interests in Microphotoacoustics, Inc., CalPACT, LLC, and Union Photoacoustic Technologies, Ltd., which did not support this work.

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