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Published December 2020 | Supplemental Material + Published
Journal Article Open

Transcranial photoacoustic computed tomography based on a layered back-projection method

  • 1. ROR icon California Institute of Technology


A major challenge of transcranial human brain photoacoustic computed tomography (PACT) is correcting for the acoustic aberration induced by the skull. Here, we present a modified universal back-projection (UBP) method, termed layered UBP (L-UBP), that can de-aberrate the transcranial PA signals by accommodating the skull heterogeneity into conventional UBP. In L-UBP, the acoustic medium is divided into multiple layers: the acoustic coupling fluid layer between the skull and detectors, the skull layer, and the brain tissue layer, which are assigned different acoustic properties. The transmission coefficients and wave conversion are considered at the fluid–skull and skull–tissue interfaces. Simulations of transcranial PACT using L-UBP were conducted to validate the method. Ex vivo experiments with a newly developed three-dimensional PACT system with 1-MHz center frequency demonstrated that L-UBP can substantially improve the image quality compared to conventional UBP.

Additional Information

© 2020 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Received 20 August 2020, Revised 28 September 2020, Accepted 29 September 2020, Available online 16 October 2020. We thank Samuel Davis for close reading of the manuscript. This work was sponsored by the United States National Institutes of Health (NIH) grants R01 CA186567(NIH Director's Transformative Research Award), R35 CA220436 (Outstanding Investigator Award), U01 NS099717 (BRAIN Initiative), U01 EB029823 (BRAIN Initiative), and Caltech internal funds (PPF0021). Declaration of Competing Interest: L.V.W. has a financial interest in Microphotoacoustics, Inc., CalPACT, LLC, and Union Photoacoustic Technologies, Ltd., which, however, did not support this work. The other authors declare no competing interests.

Attached Files

Published - 1-s2.0-S2213597920300537-main.pdf

Supplemental Material - 1-s2.0-S2213597920300537-mmc1.mp4


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August 22, 2023
December 8, 2023