Pachytene piRNAs as beneficial regulators or a defense system gone rogue
Pachytene Piwi-interacting RNAs (piRNAs) are abundant small non-coding RNAs expressed in mammalian germ lines. A new study indicates that, among the diverse pool of piRNA sequences, a small number act as highly selective guides that induce cleavage of coding and non-coding transcripts, thus promoting piRNA generation and regulating gene expression.
© 2020 Springer Nature Limited. Published 29 June 2020. The author declares no competing interests.